NettetGenetic background refers to the genetic make-up of the mouse strain (s) which have been used to produce the genetically altered (GA) mouse. This is usually one or two … Nettet13. apr. 2024 · Each time a mouse is mated to another mouse of a different genetic background, the relative strain contribution to the progeny is altered and will impact …
High-Speed Mouse Backcrossing Through the Female Germ Line
Nettet17 rader · 4. apr. 2024 · The numbers following the letters (e.g., P3) distinguish the different 129 parent strains within each lineage. These nomenclature changes affect … Nettet9. sep. 2013 · Much information is available on B6C3F1 (C57BL/6 female × C3H or C3H/He male) as a result of toxicology studies. 35,43,70 Lesions of B6;129 mice, commonly used as a background strain in genetically engineered mice, are also well described. 27,74 Gross and histological lesions of strains commonly used to generate … cindy mcwilliams grand haven mi
Phage therapy for pulmonary infection of mice IDR
Nettet31. mar. 2010 · Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2JBax+/− mice exhibited complete resistance to nerve damage after 2 weeks (similar to Bax−/− mice), … NettetAnimals. Three different mouse strains were used in this study: C57Bl/6J, 129S, and the mixed background Bl6/129S. Both male and female mice were used (n = 10 animals … Nettet18. aug. 2016 · The original Rag2 knockout mutation was made in CCE ES cells derived from the 129S6 inbred strain. The resulting mutant mice were on the 129S6 background. As researchers wanted to be able to study this mutation on the popular B6 background, the line was backcrossed 12 generations to C57BL/6NTac to make a congenic strain. diabetic cramping