Webered nickel-pincer nucleotide (NPN) cofactor (2). Homologs of LarA use NPN to catalyze racemization and epimerization reactions of a variety of α-hydroxy acid compounds other than lactate (3). The biosynthesis of the NPN cofactor in L. plantarum requires three proteins that are encoded with LarA in the lar operon (Fig. 1)(4, 5). Web28 sep. 2024 · The biosynthesis of the NPN cofactor in L. plantarum requires three proteins that are encoded with LarA in the lar operon ( Fig. 1) (4,5).
Biological Pincer Complexes - Nevarez - Wiley Online Library
Web10 jan. 2024 · The nickel–pincer nucleotide (NPN) cofactor discovered in lactate racemase from Lactiplantibacillus plantarum (LarA Lp) is essential for the … Web10 nov. 2024 · The nickel-pincer nucleotide (NPN) cofactor discovered in lactate racemase from Lactiplantibacillus plantarum (LarA Lp ) is essential for the activities of racemases/epimerases in the highly diverse LarA superfamily. Prior mechanistic studies have established a proton-coupled hydride-transfer mechanism for LarA Lp , but direct … body \u0026 brain yoga tai chi valley
New metal cofactors and recent metallocofactor insights
WebJian Hu, Robert P. Hausinger, in Comprehensive Natural Products III, 2024. Abstract. A recently discovered nickel-containing, dithioacid-modified pyridinium mononucleotide, termed the nickel-pincer nucleotide (NPN) cofactor, is present in microbial lactate racemase (LarA).Three enzymes synthesize NPN from nicotinic acid adenine dinucleotide: LarB … Web10 aug. 2024 · Bacterial lactate racemase is a nickel-dependent enzyme that contains a cofactor, nickel pyridinium-3,5-bisthiocarboxylic acid mononucleotide, hereafter named … Web1 dec. 2024 · This Opinion describes the most recently discovered metal cofactor, a nickel-pincer nucleotide (NPN) coenzyme that is covalently tethered to lactate racemase from … body \u0026 brain yoga tai chi torrance