Phenytoin definition
Webnoun A crystalline compound, C 15 H 11 N 2 O 2, used as an anticonvulsant. Webster's New World Similar definitions (medicine) An anticonvulsant drug, 5,5-diphenylimidazolidine-2,4 … Web26. jan 2024 · Phenytoin is a commonly prescribed anticonvulsant used to treat most types of seizure disorders and status epilepticus. It is not effective for treatment of absence seizures and it is no longer...
Phenytoin definition
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WebPhenytoin (Dilantin) is known to increase the risk of serious birth defects, especially when taken by the mother early in the pregnancy. If a woman takes phenytoin (Dilantin) in the 1st trimester, there is a 5 to 10% chance that her unborn baby will get Fetal Hydantoin Syndrome, which causes slower growth and brain development. Please speak with your provider if … WebPhenytoin is an anticonvulsant with a narrow therapeutic index. 5 Although the recommended therapeutic range is cited to be between 10-20 mg/L, differences in albumin levels, genetics, comorbidities, and body composition can make achieving an ideal phenytoin dose challenging. 5 For example, studies have confirmed that phenytoin …
Web2. jún 2024 · Phenytoin is used as both an abortive and preventive medication in seizure management. [ 1, 2, 3] The total phenytoin reference range varies by age, as follows: Children and adults: 10-20 µg/mL... Web15. feb 2024 · The authors state that nitrofurantoin is known to interact with phenytoin and cause reduced levels of phenytoin. However, in the current scenario, the patient developed phenytoin toxicity, the exact cause of which, remains unclear. The authors state that there is a possibility of an inadvertent overdose, or concomitant use of other unspecified ...
WebPhenytoin, a widely used antiepileptic drug, has a narrow therapeutic index and large inter-patient variability, partly due to CYP2C9 genetic variation. Patients with the CYP2C9 poor metabolizer phenotype may require reduced doses of phenytoin. Additionally, the HLA-B*15:02 variant is associated with an increased risk of phenytoin-induced cutaneous … Webnoun A crystalline compound, C 15 H 11 N 2 O 2, used as an anticonvulsant. Webster's New World Similar definitions (medicine) An anticonvulsant drug, 5,5-diphenylimidazolidine-2,4-dione, used in the treatment of epilepsy. Wiktionary Synonyms: dilantin diphenylhydantoin Advertisement Other Word Forms of Phenytoin Noun Singular: phenytoin Plural:
Web1. sep 2013 · Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics. However, serum drug levels should only be taken when there is a clear indication to guide patient ...
WebPhenytoin is an anticonvulsant that inhibits the release of insulin by beta cells and may also directly impair the effects of insulin on peripheral tissues (Haemers and Rottiers, 1981). Unfortunately, phenytoin is not usually successful in controlling clinical signs of … bowl diffuserWeb11. aug 2024 · Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9.Furthermore, the variant allele HLA-B*15:02 is associated with an increased risk of Stevens–Johnson syndrome and toxic epidermal necrolysis in response to phenytoin … bowl dictionaryWebphen·y·to·in. (fĕn′ĭ-tō′ĭn, fə-nĭt′ō-) n. An anticonvulsant drug, C 15 H 12 N 2 O 2, used to treat epilepsy, often in the form of its sodium salt. Also called diphenylhydantoin. [ (di)pheny (lhydan)toin.] American Heritage® Dictionary of the English Language, Fifth Edition. bowl design ideashttp://dictionary.sensagent.com/Fosphenytoin/en-en/ bowl depth gaugeWeb15. jan 2024 · Phenytoin is a Vaughn Williams Class IB antiarrhythmic; although, it is almost never used as an antiarrhythmic anymore. Its effects on the cardiac voltage-gated sodium channels can lead to dysrhythmias as well as SA and AV nodal blocks although such effects have rarely been reported following ingestion of the oral form. gulliver galvanized lightingWebPhenytoin is metabolized by the cytochrome P450 enzymes CYP2C9 and CYP2C19. Phenytoin hepatic metabolism is saturable, and following administration of single IV CEREBYX doses of 400 to 1200 mg PE, total and unbound phenytoin AUC values increase disproportionately with dose. Mean total phenytoin half-life values (12.0 to 28.9 hr) bowl depth guageWeb14. apr 2024 · Phenytoin belongs to a class of drugs called antiepileptic drugs (AEDs). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar... bowl designs for woodturning